Abstract
Twenty six lambs divided into four groups were used to study the effect of experimental infection with two challenge doses of D.filaria ( 100 & 300 larvae / Kg. B. W.) on the aquired immunity after vaccination with irradiated larval vaccine “ Filiraq”. The clinical symptoms , eosinophi lic response, blood picture, faecal larval counts, gross pathological changes & adult worm counts in the lungs were studied ... 
 The results showed that a high dose of challenge (300 LI kg) prevents the development of expected acquired immunity, however the other vaccinated & challenged group ( 100 LI Kg B.W ) showed good level of acquired immunity in comparison with other group.
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