Abstract
Background: In poultry production, improving immunity is very important to prevent infectious diseases. One solution to improve the immunity of animals and to decrease their susceptibility to infectious disease is administration of immunostimulants. Surveys have indicated that some bacteria can work as immunomodulators such as Mycobacterium vaccae and can promote Th1-mediated mechanisms, and switch off pre-existing Th2 preponderance (1). Objectives: The aim of this study was to examine the effect of Tsukamurella inchonensis bacterin on the immune response against Influenza and Newcastle disease vaccine in broiler chickens . Materials and Methods: A total of 170 day-old broiler chicks were purchased and divided randomly into 5 equal groups. Chickens of group A received 106 bacterin subcutaneously on two days before vaccination against Newcastle disease and avian influenza. Chickens of group B received 106 bacterin subcutaneously on six days after the first injection of bacterin. Chickens of group C received 106bacterin subcutaneously on six days after the second injection of bacterin. Chickens of group D, vaccinated against Newcastle disease and avian influenza but did not receive bacterin. Chickens of group E, did not vaccinate against Newcastle disease and avian influenza and did not receive bacterin. All groups except group E, were vaccinated with live Newcastle vaccine and AI-ND killed vaccine (subtype H9N2). Blood samples were collected and antibody titer against Newcastle disease vaccine and avian influenza vaccine was determined by HI test. Results: The results of present study showed that receiving of Tsukamurella inchonensis bacterin for 3 times, significantly increased the specific antibody response to avian influenza subtype H9N2 vaccine. Also about Newcastle vaccine, significantly increased the specific antibody response to Newcastle vaccine at 21 and 28 days after vaccination. Conclusions: Receiving of Tsukamurella inchonensis bacterin can enhance immune response against NDV and AIV.
Highlights
In poultry production, improving immunity is very important in preventing infectious diseases
Studies have indicated that some bacteria such as Mycobacterium vaccae can work as immunomodulators promote Th1-mediated mechanisms, and switch off pre-existing Th2 preponderance.[1]
Actinomycetales species closely related to mycobacteria, including Rhodococcus coprophilus (Rc), Gordonia bronchialis (Gb), and Tsukamurella inchonensis (Ti), which have immunomodulatory or adjuvant activities when injected as suspension of killed bacilli, have been identified.[17,18]
Summary
In poultry production, improving immunity is very important in preventing infectious diseases. Surveys have indicated that some bacteria such as Mycobacterium vaccae can work as immunomodulators, promote Th1-mediated mechanisms, and switch off pre-existing Th2 preponderance.[1] Objectives: The aim of this study was to examine the effect of Tsukamurella inchonensis bacterin on the immune response against influenza and Newcastle disease (ND) vaccines in broiler chickens. Chickens of group A received 106 bacterin subcutaneously 2 days before vaccination against ND and avian influenza (AI). Chickens of group B received 106 bacterin subcutaneously 6 days after the first injection of bacterin. Chickens of group C received 106 bacterin subcutaneously 6 days after the second injection of bacterin. Results: The results of present study showed that receiving T. inchonensis bacterin for 3 times significantly increased the specific antibody response to AI subtype H9N2 vaccine. They have negative-strand RNA, are segmented, and have three types, A, B, and C.3 Avian influenza viruses (AIVs) belong to type A, but all three types of influenza
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
