Abstract
目的观察雷公藤多甙对小肠移植急性排斥反应的治疗作用.方法选用近交系大鼠F344/N和Wistar/A进行全小肠异位移植,实验分3组,第1组:非治疗对照组(F344-Wistar);第2组:CsA治疗对照组[F344-Wistar+Csa(6mg,肌肉注射)];第3组:雷公藤多甙治疗组[F344 -Wistar+雷公藤多甙(50mg/kg,灌胃)].观察动物存活及一般状况,并于术后第3、5、7d取移植肠标本进行病理学检查.结果第1组大鼠存活时间(6.83±0.41)d,第3组大鼠存活时间为(8.00±0.63)d,二者间有极显著差异(P<0.01),第2组大鼠存活均超过10d,并于10d时处死.病理检查显示第1组术后第3d发生轻度排斥,第5d发生中度排斥,第7d发生重度排斥;第2组除部分标本在术后第5、7d发生轻度排斥外,无排斥征象;第3组与第1组改变相似,但排斥的病理改变发生较晚、较轻.结论对小肠移植急性排斥的治疗,在50mg/kg剂量水平上单独使用雷公藤多甙,其免疫抑制作用是明确的,但疗效有限.
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