Abstract
The effect of α-trinositol (D-myo-inositol-1,2,6-trisphosphate) on cholera toxin–induced fluid accumulation (i.e., net fluid secretion) was studied in the pig jejunum in vivo. Cholera toxin caused a dose-dependent fluid accumulation in control experiments. Intravenous injection of α-trinositol produced a reduction of the response to cholera toxin with a significant maximal inhibition of 36%. However, in high concentrations of α-trinositol this inhibition was absent.
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More From: Comparative Biochemistry and Physiology -- Part A: Physiology
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