Abstract
In guinea pig ileal muscle strips, trifluoperazine (TFP) inhibited the high K+-induced contraction with an IC50 of 1.9 μM and the Ca2+-induced contraction in skinned fiber with an IC50 of 44 μM. TFP decreased the high K+-induced increase in cytoplasmic Ca2+ level at the concentration 3 μM, which did not inhibit the contraction in skinned fiber. It is suggested that the inhibitory effect of TFP on the high K+-induced contraction is mainly due to the decrease in cytoplasmic Ca2+.
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