The Effect of Tri Poly Phosphate Concentration towards Chitosan-Alginate Micro-particle Characterization and Dissolution Process in Acidic Medium

Abstract

Chitosan-Alginate micro-particles can serve as coating to the drug through the encapsulation process for controlled release. The addition of Tri Poly Phosphate would change the characterization of Chitosan-Alginate micro-particles because of the process of cross linking. This study aims to determine the characterization of micro-particles of Chitosan-Alginate based on particle size distribution, particle surface morphology and dissolution process in acid medium. The method used to make micro-particles of Chitosan-Alginate is using spray drying, thus the micro-particles can be made by mixing Chitosan-Alginate with a weight ratio of 1: 1, 1: 2, 2: 1 then mixed the crosslinking compound Tri Poly Phosphate (TPP) with a concentration of 0.1%, 0.3%, 0.5%, and added emulsifier Tween 80 3% v / v, stirred at a speed of 20,000 rpm for 10 minutes then inserted into the spray dryer to form micro-particles. The powder of micro-particles then analysed by Scanning Electron Microscopy (SEM) and performed in vitro of stomach acid solution using acidic medium for the test of dissolution. Based on the research that has been done, 0.1% TPP concentration of Chitosan-Alginate ratio of 2: 1 can produce the most uniform size distribution with a ratio of 40.54%. The biggest dissolution of micro-particles obtained from the samples with Chitosan-Alginate ratio of 2: 1 with a concentration of 0.1% TPP was 80.8%.