Abstract
Purpose: This study was conducted to detect IL-6 in synovial fluid in cases with TMJ internal derangement. Patients & Methods: This study was conducted on forty patients ASA class I with TMJ Internal derangement. All patients had been subjected to arthrocentesis. The synovial fluid was collected before wash and lavage was done for the affected joint. Then, the selected patients were divided randomly into two equal groups, group I: consisted of 20 patients where arthrocentesis was performed for the affected joint followed by intraarticular injection of one ml, tramadol hydrochloride. Group II: consisted of 20 patients where arthrocentesis was performed for the affected joint followed by intraarticular injection of one ml. sodium hyaluronate. Another synovial fluid sample was aspirated after one month. The interlieukin-6 receptors in the aspirated synovial fluid were measured using humans IL-6 enzyme-linked immunosorbent assay. Results: IL-6 was detected in the synovial fluid of joints with internal derangement. During follow up assessment of IL-6, the maximum decrease in IL-6 level was in the patients of group I who subjected to arthrocentesis with tramadol injection, as the mean IL-6 was (4.93 ± 1.36) followed by the patients of group II who subjected to arthrocentesis with sodium hyaluronate injection where the mean IL-6 level was (6.88 ± 1.76). There were significant p-value = (P = 0.000). Conclusions: It had been concluded that the detection of IL-6 in the synovial fluid of joints with internal derangement considered an indicator for inflammatory reaction in the joint and also the efficacy of arthrocentesis with tramadol suggested its anti-inflammatory effect.
Highlights
Anterior disc displacement of the Temporomandibular Joint (TMJ) is defined as a malrelationship of the disc to the condylar head and articular eminence
Group II: This group consists of 20 patients where arthrocentesis was performed for the affected joint followed by intraarticular injection of one ml. commercially available sodium hyaluronate
There were no significant changes in the mean IL-6 level between the two study groups at the preoperative assessment .Table 2, Figure 8
Summary
Anterior disc displacement of the TMJ is defined as a malrelationship of the disc to the condylar head and articular eminence. Internal derangements can be divided into 2 categories: anterior disc displacement with reduction and anterior disc displacement without reduction. The condition in which the disc is located anteriorly and slips back into its normal position during opening of the mouth is called anterior disc displacement with reduction; the opposite condition is dubbed anterior disc displacement without reduction [1]. Internal derangements of the Temporomandibular Joint (TMJ) are characterized by displacement of the intra-articular disc, which acts as an obstacle to normal joint movement. It results in clicking and popping sounds or locking and an inability to open the mouth widely. These conditions may be associated with pain, especially during function, the most common causes are trauma or chronic parafuntion [2]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
