Abstract
The Effect of Training on Motoneuron Survival in Amyotrophic Lateral Sclerosis: Which Motoneuron Type is Saved?
Highlights
Deforges et al (2009) examined the effect of two training exercise paradigms on MN survival and muscle fiber composition in the G93A mouse model of Amyotrophic lateral sclerosis (ALS)
Training exercise was performed through 30 min daily running or swimming sessions that started at postnatal day 70 (P70) and lasted until P115 or death
MN count, and muscle fiber composition were assessed at P115 in the fast twitch muscles tibialis and plantaris and the slow twitch soleus muscle of the G93A mouse groups, and were compared to normal, non-transgenic, and untrained G93A transgenic mice
Summary
Deforges et al (2009) examined the effect of two training exercise paradigms (i.e., running and swimming) on MN survival and muscle fiber composition in the G93A (high expressor line) mouse model of ALS. They had higher MN total number and higher proportion of medium-size MNs relative to the sedentary ALS group, and maintained muscle fiber composition in all muscles similar to the control group.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
