Abstract
BACKGROUNDIschemia of skin flaps is an important complication in reconstructive surgery. This study evaluated the efficacy of topical vitamins A and E on improving flap survival. METHODSTwenty-four white-albino male rats were randomly divided into two groups of treatment and control. Standard rectangular, distally based dorsal random pattern skin flap was elevated. Intra-peritoneal cephazoline was administered to prevent any unexpected infection. No pharmaceutical agent was administered for the control group, but pure vaseline ointment. In treatment group, vaseline plus vitamins A and E were administrated daily after surgery for 10 days. The rats were evaluated on the 10th day after surgery for viable and necrotic portions of the flaps. RESULTSThe mean values of necrosis in the flaps were 625±189.56 and 920.00±247.31 in the treatment and control groups, respectively. Vaseline plus vitamins increased flap survival significantly.CONCLUSIONTopical vitamins A and E may be effective pharmaceutical agents to increase viability of random skin flaps in rats. They can be added to vasoactive topical agents to reach better results.
Highlights
Improvements of reconstructive fields such as burns, congenital deformities, tumor resections, trauma sequels and even aesthetic issues enhanced expectations
Topical vitamins A and E may be effective pharmaceutical agents to increase viability of random skin flaps in rats. They can be added to vasoactive topical agents to reach better results
Random skin flap has been used for many years with acceptable outcomes
Summary
Improvements of reconstructive fields such as burns, congenital deformities, tumor resections, trauma sequels and even aesthetic issues enhanced expectations. Reconstructive surgery as a remarkable life boat, uses flaps as its work horses. Random skin flap has been used for many years with acceptable outcomes. Despite tremendous progress in the past decades, flap surgery is still associated with a considerable morbidity. An important complication is ischemia of the flap –especially on the distal potion.[1] www.wjps.ir /Vol.8/No.1/January 2019. Lots of clinical trials have tried to find ways to reduce distal flap necrosis. The delayed procedure can be very useful, but requires additional surgical interventions, takes a great deal of time, and can be assumed invasive.[2] The factors involved in distal skin flap necrosis are either extrinsic or intrinsic. The only significant intrinsic factor is arterial insufficiency.[3]
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