Abstract
It has previously been shown that regeneration of cortical tissue from the capsule of an enucleated adrenal gland occurs when the opposite gland is removed (1). The presence of one intact adrenal gland suppresses regeneration in the other enucleated gland. Likewise, regeneration of cortical tissue in an enucleated gland may be completely suppressed by the administration of cortin (1). Thus it seems clear that the physiologic requirement by the organism for cortical hormone is an important factor influencing the regeneration of the adrenal cortex. It is well known that the administration of thyroxine to the normal animal produces hyperplasia of the adrenal cortices. When thyroxine is administered to the adrenalectomized dog, the maintenance requirements for cortin are increased (3). Since thyroxine induces cortical hyperplasia in the adrenal glands of normal animals, will it increase the extent of cortical regeneration within enucleated adrenal glands?
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