Abstract
Both T3 and SUS influence the myosin isoform content and maximal shortening velocity (Vmax) of slow skeletal muscle. This study tested the following hypothesis: the concomitant administration of T3 and SUS will produce an additive effect, increasing Vmax beyond that produced by either intervention alone. Female Sprague-Dawley rats were assigned to: i) control,n=9; ii) T3, n=9; iii) SUS;n=9; or iv) T3+SUS, n=9. T3 and T3+SUS animals received daily injections of T3 during the 28 days that animals were suspended. At the end of this period, in situ contractile measurements were made. A one-way ANOVA demonstrated that there was a significant difference (P<0.001) among the groups. The Tukey HSD test revealed that T3+SUS produced an increase in Vmax that was greater than that produced by either T3 or SUS alone. Several models of single muscle fiber plasticity might explain these results: i) T3 and SUS act on the same fibers, and when combined increase the fast myosin content above that observed when either is administered alone; or ii) T3 and SUS act on entirely different populations of fibers. Table
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