Abstract
It is well known that the feeding of thyroid extract to frog larvae accelerates the process of metamorphosis. One aspect of this change, which may readily be noted a few days after the first thyroid administration, is a definite protrusion of the eyeballs. Huxley and Hogben 1 have pointed out that this is apparently comparable to the exophthalmic condition in man associated with exophthalmic goiter. The object of the present study is to determine as nearly as possible the mechanism by which the change in the eye of the thyroid-treated tadpole is accomplished. Tadpoles (Rana catesbeiana) of about 6 cm. in length constitute the material used. Microscopic examinations of eyes from normal tadpoles, and of eyes from animals killed at intervals varying from one to thirty-three days after the first thyroid feeding, supply the data on which the conclusions are based.2These observations are supplemented by gross anatomic dissections of
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