Abstract
The present study investigates the effect of a partially purified thymus factor, thymosin Fraction 5, and an homogeneous polypeptide component of Fraction 5, thymosin α 1, on glucocorticoid resistance and glucocorticoid receptors in mouse thymocytes. Treatment of thymocytes in vitro with thymosin Fraction 5 or α 1, results in an increase in the percentage of glucocorticoid-resistant cells. Studies on the specific whole-cell binding of [ 3H]dexamethasone and steroid competition experiments demonstrate the existence of high-affinity ( K d = 1.0 × 10 −8 M) specific glucocorticoid receptors in mouse thymocytes. Preincubation with thymosin Fraction 5 or α 1 appears to cause a reduction in the specific [ 3H]dexamethasone binding to intact thymocytes.
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