Abstract

The thymosin α1 C-terminal fragment H-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH (positions 14-28) was synthesized by a conventional method. Two thymosin α1 fragments, H-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH (positions 19-28) and the pentadecapeptide fragment synthesized in this study, were tested for effect on lymphocyte transformation in the uremic state. The synthetic pentadecapeptide increased 3H-thymidine incorporation into DNA in the uremic state, but the synthetic decapeptide had no effect on the 3H-thymidine incorporation.

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