Abstract
The effect of a single oral dose of three monoamine oxidase inhibitors, Marplan [1-benzyl-2-(5-methyl-3-isoxazolylcarbonyl) hydrazine], Parnate sulfate (cis-trans-phenylcyclopropylamine sulfate) and Nardil (β-phenylethylhydrazine) on human plasma monoamine oxidase was determined by the radioassay of Otsuka and Kobayashi, Biochem. Pharmac. 13, 995 (1964). Parnate was the only drug that effected definite inhibition of the plasma enzyme. It was suggested that plasma monoamine oxidase titers can be used to monitor in vivo the effectiveness of monoamine oxidase inhibitor drugs.
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