Abstract
Objective: to study molecular effects of thiotriasoline of the patients with coronary heart disease (CHD). Materials and methods: 60 patients with stable angina of I – III functional classes were compared regarding the effects of thiotriasoline via standard therapy regime (STR), taking into account the activity of basic products level free radical oxidation (FRO) and antioxidant systems (AOS), proteomic protein profile. Results: in 24 weeks on the background of STR and thiotriasoline there is a revealed statistically reliable growth of glutathione reductase content, reduction of malonic dialdehyde, increase of endothelial lipase detection rate, phosphomevalonatekinase, γ-butyrobetaine hydroxylase, linoleil CoA-desaturase, reduction of delta-5 desaturase. Conclusion: thiotriasoline possesses cardioprotective activity with antioxidant and cytoprotective effects, reducing free radical products content and raising the activity of antioxidant systems ferments with regard to patients with CHD.
Highlights
Для цитирования: Кастанаян А.А., Карташова Е.А., Железняк Е.И
Materials and methods: 60 patients with stable angina of I – III functional classes were compared regarding the effects of thiotriasoline via standard therapy regime (STR), taking into account the activity of basic products level free radical oxidation (FRO) and antioxidant systems (AOS), proteomic protein profile
В I и II группах отмечалось статистически достоверное увеличение количества пациентов, у которых было выявлено наличие в плазме крови экспрессии белка GCN5 (p
Summary
ВЛИЯНИЕ ТИОТРИАЗОЛИНА НА ПРОЦЕССЫ ЭНЕРГООБРАЗОВАНИЯ В УСЛОВИЯХ ХРОНИЧЕСКОЙ ИШЕМИИ МИОКАРДА. Цель: изучить молекулярные эффекты тиотриазолина у пациентов с ишемической болезнью сердца (ИБС). Материалы и методы: у 60 пациентов со стабильной стенокардией напряжения I – III функционального класса сравнивались эффекты тиотриазолина со стандартным режимом терапии (СРТ), учитывая активность уровня основных продуктов свободнорадикального окисления (СРО) и антиоксидантных систем (АОС), протеомный профиль белков. Objective: to study molecular effects of thiotriasoline of the patients with coronary heart disease (CHD). Materials and methods: 60 patients with stable angina of I – III functional classes were compared regarding the effects of thiotriasoline via standard therapy regime (STR), taking into account the activity of basic products level free radical oxidation (FRO) and antioxidant systems (AOS), proteomic protein profile. Conclusion: thiotriasoline possesses cardioprotective activity with antioxidant and cytoprotective effects, reducing free radical products content and raising the activity of antioxidant systems ferments with regard to patients with CHD.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
