Abstract
Accidental radiation exposure raises concern for functional modifications in the uterine physiology. In the current work, total body γ-irradiation (0.7, 1.4 and 2.1 Gy) of non-pregnant adult female albino rats increased significantly the frequency and amplitude of uterine contractions in vivo. Administration of Thiola (a sulfhydryl containing agent) in doses of 100 or 250mgkg −1, pre-irradiation, or Piroxicam (a potent prostaglandin inhibitor) in a dose of 2mgkg −1, pre- or post-irradiation failed to normalize the changes induced by γ-irradiation. However, administration of Diltiazem (a Ca 2+channel blocker, 8mgkg −1) pre- or post-irradiation caused a significant decrease in the frequency of uterine contractions (21% and 24% respectively) in comparison to the uterotonic pattern of γ-irradiation alone. The results indicate a promising tocolytic activity of Diltiazem against the uterotonic effect of γ-radiation.
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