Abstract
In this study, tantalum coatings are deposited by a plasma spraying method aiming at enhancing the biocompatibility of the titanium implant. Tantalum oxide coatings are gained through the thermal oxidation of tantalum coatings at different temperatures for photothermal therapy. The effect of thermal oxidation on the morphology, composition, and structure of tantalum coatings has been studied. The UV–VIS–NIR spectra results, cancer therapy effect in vitro, and photothermal conversion properties among the tantalum oxide coatings under varied thermal treatment conditions are compared comprehensively. It has been proven that the tantalum coating treated at 200 °C exhibits the most intense NIR adsorption, the highest photothermal conversion effect, and the most excellent photothermal ablation effect in vitro. The results reveal that incomplete oxidation at a low temperature leads to the formation of oxygen vacancies, which narrow the band gap; this promotes its photothermal conversion ability.
Highlights
IntroductionTantalum (Ta) and its oxides are gaining increasing interest for their excellent biocompatibility [1,2,3]
Plasma-sprayed tantalum coating with a high bonding strength and a porous surface structure is suitable for metal implants, as the biological performance can be improved by combining the substrate with such biocompatible and corrosion-resistant surfaces [4,5]
Our study aims to explore a way to achieve a bifunctional surface modification layer that can be used post-surgery for bone cancer photothermal therapy
Summary
Tantalum (Ta) and its oxides are gaining increasing interest for their excellent biocompatibility [1,2,3]. Plasma-sprayed tantalum coating with a high bonding strength and a porous surface structure is suitable for metal implants, as the biological performance can be improved by combining the substrate with such biocompatible and corrosion-resistant surfaces [4,5]. Metal implants of titanium and its alloy have been used extensively for hard tissue disorder treatments, owing to their excellent mechanical properties and biocompatibility [6]. Some studies have demonstrated that plasma-sprayed tantalum coating can enhance the osteogenic properties of the titanium implant in the early stage [7,8,9]
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