Abstract
To investigate the effects of systemic administration of Theranekron (Tarantula cubensis) extract as homeopathic remedy on anastomosis healing after surgical intestinal resection. Eight healthy stray dogs (age 1-1.5 years, weight 15-20 kgs) were randomly divided into two groups; control (4 animals) and treatment group (4 animals). Intestinal resection and anastomosis were performed in all animals in both groups. Theranekron D6 (3 ml) was administered subcutaneously one week before surgery and at operation time in the treatment group whereas animals of the control group were injected 3 ml of normal saline at the same time points of treatment group. All animals were kept for 15 days following surgery and a segment of intestine was removed for histopathological and press pressure measurement. The results showed that no post-operative complications have been observed in both groups. The gross examination of the anastomosis site revealed sever adhesions with omentum and other intestinal segment of the all animals of the control group in comparison to the treatment group where lesser adhesions with omentum without any adhesion with the other intestinal segment have been noticed. There was slight difference between control and treatment group in relation to histopathological examination. In conclusion, the findings of this study showed that Theranekron was able to improve the healing process of the resected and anastomosed intestinal segment
Highlights
Intestinal anastomosis can be defined as the creation of a connection between two intestinal segments to re-establish intestinal continuity
Therankerone 3 ml was injected at time of surgery and seven days later in the treatment group where as normal saline was injected in the control group
Other complications related to intestinal surgery in dogs such as leakage and stricture were not observed in the both control and treatment groups
Summary
Intestinal anastomosis can be defined as the creation of a connection between two intestinal segments to re-establish intestinal continuity. An intestinal anastomosis becomes necessary when resection of a segment on the gastrointestinal tract is performed for benign or malignant indications and gastrointestinal continuity needs to be restored (1). The basic and simple objective of sutured or stapled anastomosis construction is to ensure an appropriate edgeto-edge apposition for healing. Intestinal anastomosis is evaluated by many common parameters such as histologic healing (microcirculation and adhesion formation), bursting, breaking, tensile strength and luminal diameter, morbidity and mortality (5). The most common indications for intestinal resection and anastomosis include many affections such as intestinal neoplasia, intussusception, ischemia and trauma. The main objective of this study was to assess mechanically and histologically the effect of therankeron D6 on healing process of intestinal anastomosis in dogs
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