Abstract
The BDB-hemagglutinating properties of six different antigen-antibody systems were studied. In each case two tests were performed in which the erythrocytes were sensitized by the addition of BDB either before or after the addition of the antigen It was found that in those systems where the antigenic determinants were protein in nature the two methods of sensitization gave rise to virtually identical titers. However, in the systems in which the antigens contained phenolic and/or carbohydrate determinant groups, markedly higher titers were obtained if the BDB was mixed with the erythrocytes before rather than after the addition of the antigenic material. It is suggested that the nonspecific adsorption of carbohydrate and phenolic groups onto red cell surfaces in the absence of BDB is the most likely explanation for this phenomenon. This dual method of BDB hemagglutinin has potential applications as a method of investigating the chemical nature of antigenic determinants of unknown composition.
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