Abstract
Magnesium stearate was mixed with different sieved fractions (80–180, 180–250, 250–350 μm) of microcrystalline cellulose (Avicel PH 102). The influence of mixing time on crushing strength and disintegration of tablets compressed from these mixtures were studied. The disintegration time increased and the crushing strength decreased with increasing particle size of the Avicel fractions. When magnesium stearate is mixed with table excipients the size of these materials could have an effect on the deterioration of the tablet properties as a function of mixing time.
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