The Effect of the Extracellular Domain of Human Copper Transporter (hCTR1) on Cisplatin Activation

Abstract

Contractually binding: The methionine residues of the extracellular domain of hCTR1 (hCTR1_N) and its mutants were shown to be the key residues for cisplatin binding. hCTR1_N significantly facilitates the activation of the drug by the formation of Pt–thioether species. The anticancer drug is likely transported by hCTR1 through methionine-based sulfur–sulfur exchange (see picture). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.