Abstract
The resolution of mandelic acid and its derivatives with free amino acids has been investigated. It was observed that the corresponding diastereomers were formed under either kinetic or thermodynamic control, which considerably influenced the purity of the enantiomeric mixtures obtained. It was found that in these particular resolutions, the eutectic composition of either the racemic compound or the resolving agent influenced the purity of the enantiomeric mixtures of the mandelic acid derivatives obtained after resolution.
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