Abstract

The article presents the results of a study on the effects of the wild medicinal plant Eminium regelii Vved. extract to the body of intact and subjected to emotional stress animals on the background of a long-term low dose of gamma-radiation. The reaction of the animal organism to the effects of radiation, emotional stress and the introduction of the Е. regelii extract were evaluated by the total content of leukocytes, absolute and relative content of lymphocytes (including CD3+, CD4+, CD8+), immunoregulatory index (IRI) and leukocyte migration inhibition reaction (LMIR). The experiments were performed on adult mongrel white rats of both sexes. At the early stage of the general adaptation syndrome (GAS) the injection of Е. regelii extract caused a decrease in the total number of lymphocytes, an increase in the number of CD4+ lymphocytes and leukocytes lymphokinproduction abilities. Late stage of GAS was indicated by increased CD3+ and CD4+ lymphocytes, and increased values of the immunoregulatory index.

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