The Effect of the Drug Estrofan on the Content of Nitric Oxide (II), Sex Hormones, Biochemical Parameters and Their Relationship in Cows

I.T Sibgatullin,T.M Zakirov,R.Ya Gilmutdinov,A Valiev,W Heijman,R Nizamov,D.I Zhilyakov,I Safiullin,M Kalimullin,D.A Zyukin,F Nezhmetdinova,M Nizamutdinov,A Taylan,B Ziganshin

doi:10.1051/bioconf/20213700170

Abstract

The physiological functions of nitric oxide (II) are diverse, and its therapeutic uses continue to expand. Many methods have been found to regulate the production of this compound, both physiological, regulated by the body itself, and as a result of various, drug and non-drug, external influences, correcting the ability of cells, organs and tissues to produce nitric oxide (II). The drug estrophan (synthetic prostaglandin PGF2α) has an activating effect on the nitric oxide (II) system and on sex hormones that regulate the reproductive functions of cows. The introduction of estrophan to cows is accompanied by an increase in the synthesis of nitric oxide (II), estrogen in the body of cows, and a decrease in progesterone. A high level of interrelation of estrogen with nitric oxide (II) was shown, the value of the correlation coefficient is (r = 0.552; p < 0.05). Correlation of the level of nitric oxide (II) with estrogen allows making an assumption of its bioregulatory functions, including the sexual cycle. The introduction of estrophan had no effect on the biochemical parameters in the blood serum of cows.

Highlights

The problems of reproduction and prevention of infertility in cows under the conditions of modern industrial maintenance and exploitation, even with the significant achievements in the field of reproductive physiology, do not lose their relevance for animal husbandry [4]
We found that the content of nitric oxide (II) in the blood of cows depends on the stage of the sexual cycle
Since prostaglandins are a group of acidic lipids that are involved in a large number of reproductive processes, the stage we studied the state of the nitroxydergic system under the action of estrophan, since the understanding of the mechanism is not yet perfect, in addition, the relationship between prostaglandins and other vasoactive substances, such as nitric oxide, complicates this area and is not fully understood

Summary

Introduction

The problems of reproduction and prevention of infertility in cows under the conditions of modern industrial maintenance and exploitation, even with the significant achievements in the field of reproductive physiology, do not lose their relevance for animal husbandry [4]. With a significant number of scientific works devoted to the influence of various biologically active substances on the reproductive function of dairy cows, there is still no consensus on both the mechanisms of action and the effectiveness of these drugs [1, 2, 14, 15]. In this regard, in addition to creating favorable conditions for the implementation of their own reproductive capabilities of animals, it is promising to adjust biotechnological methods for regulating reproductive function and search for the most effective, environmentally friendly methods of preventing and treating the corresponding diseases.

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Results

Conclusion