Abstract
The aim of the study was to determine the effectiveness of the drug "Cobazin" on the productivity of bee colonies during the increase in strength (increase in the number of young bees in the bee colony) in spring and autumn.
 Materials and methods. Control and experimental groups were formed to test "Cobazin" feed supplement. It was fed 5 times with an interval of 5 days. Bee colonies from the control group received a pure sugar solution (1:1) in the amount of 0.5 liters per bee colony, and the experimental group received a sugar solution of 0.5 liters per bee colony (1:1) with the addition of the drug "Cobazin" in the amount of 2.5 g.
 Indicators characterizing the development of bee colonies were determined by a measuring frame of 5x5 cm in size, for 12 days to cover the total number of eggs laid by the queen bee during feeding. Four measurements were performed during the study. The results of the control and experimental groups were compared and the significance of the differences between them was established. There was a comparison of the difference between groups of bees both fed pure sugar syrup in a ratio of 1:1 and syrup with the addition of the drug "Cobazin".
 Results. It is proved that during the feeding period the number of brood in bee colonies that received feed supplement "Cobazin" increased significantly by 76 % (71 % in the group that received only sugar solution without this drug). Live weight of queen bees in colonies that were stimulated with "Cobazin" was actually 2 % higher compared to the control group.
 It was found that at the end of the bee season, bee colonies fed in May with the feed supplement "Cobazin" had significantly higher values of strength, number of sealed brood and live queen bees compared to those who received pure sugar solution. The brood in the control group was 25 % lower than in the experimental group.
 Conclusions. For the first time it was proved that the use of feed supplement "Cobazin" in combination with sugar solution has a positive effect on the features that characterize the development of bee colonies (strength, number of sealed brood) and their health productivity. The positive impact is observed not only during feeding, but also in subsequent periods of colony development.
Highlights
The object of the study is the developed immunomodulatory feed supplement «Cobazin»(Brovapharma Ltd.) on the basis of three active components: cobalt – 0.4 mg; zinc – 0.8 mg; germa nium – 0.08 mg.Beekeeping in modern market conditions is impossible without high profitability of apiaries
The aim of the research was to conduct experimental studies to determine the effectiveness of the use of a new immunomodulatory feed supplement «Cobazin», based on cobalt, germanium and zinc in the period of bee colonies feeding to increase the strength of bee colonies
Discussion of research results It is proved that the use of «Cobazin» feed supplement at a dose of 2.5 g/500 ml of sugar solution 5 times with an interval of 5 days has a positive effect on the characteristics of bee colonies and their health
Summary
Beekeeping in modern market conditions is impossible without high profitability of apiaries. High profitability is created by a set of conditions. Healthy bees are one of the conditions for good wintering, rapid spring development and high honey yields. One of the main tasks in the beekeeping industry is to increase the number of bee colonies and their productivity [1, 2]. Given these goals, not the last place in the stage of breeding honey bees is stimulating the reproduction of bee colonies during their development. Very often in certain periods of bee colonies deve lopment they are fed with feed, which contains stimulants [3, 4]
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