Abstract

The experimental research of the artichoke (Cynara scolymus) leaves extract (ALE) influence on the postnatal development of the I st generation rats born by female rats with the ethanol-induced placental dysfunction (PD) has been conducted. It has been found that the therapeutic and preventive regimen of ALE and the reference medicine Solcoseryl from the 14 th to the 19 th day of gestation (on the background of introduction of 40% ethanol solution in the dose of 4 g/kg) reduced the level of death in infant rats: ALE in 2.4 times and Solcoseryl in 1.6 times compared to the untreated control. The medicines studied caused a significant weight gain in rats compared to the control pathology group. From the 1 st to 14 th days of the experiment the weight gain caused by ALE was more significant. The difference in the efficacy of the medicines was not further observed. Introduction of ALE and Solcoseryl also promoted the correction of pathological deviations in the postnatal development of infant rats. Moreover, ALE showed a higher activity compared to Solcoseryl. Therefore, the data obtained allow to recommend ALE for the preventive correction of alcoholic embryopathy developed on the background of PD.

Highlights

  • The experimental research of the artichoke (Cynara scolymus) leaves extract (ALE) influence on the postnatal development of the Ist generation rats born by female rats with the ethanol-induced placental dysfunction (PD) has been conducted

  • The aim of the work was to study the effect of ALE on the postnatal development of infant rats of the 1st generation born by female rats with alcoholic PD

  • At the same time the quantity of dead infant rats born by female rats treated with the reference medicine Solcoseryl was only 1.6 times less than in untreated animals

Read more

Summary

Introduction

The experimental research of the artichoke (Cynara scolymus) leaves extract (ALE) influence on the postnatal development of the Ist generation rats born by female rats with the ethanol-induced placental dysfunction (PD) has been conducted. It is known that alcohol can cross the placental barrier, accumulate in the amniotic fluid and have the embryolethal, teratogenic, and the general toxic effect on a fetus [6, 8, 11]. It results in formation of the fetal alcoholic syndrome, which is characterized with growth retardation, mainly expressed within the first months and years of the postnatal period, delay in physical and mental development of children, etc. The aim of the work was to study the effect of ALE on the postnatal development of infant rats of the 1st generation born by female rats with alcoholic PD

Objectives
Methods
Results
Conclusion
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call