Abstract
PurposeRecent studies on temperature control in biology and medicine have found the temperature as a new instrument in healthcare. In this manuscript, we reviewed the effects of temperature and its potential role in pars plana vitrectomy. We also examined the relationship between intraocular pressure, viscosity, and temperature in order to determine the best balance to manipulate the tamponades during the surgery.MethodsA literature review was performed to identify potentially relevant studies on intraocular temperature. Physics equations were applied to explain the described effects of temperature changes on the behavior of the endotamponades commonly used during vitreoretinal surgery. We also generated an operating diagram on the pressure–temperature plane for the values of both vapor–liquid equilibrium and intraocular pressure.ResultsThe rapid circulation of fluid in the vitreous cavity reduces the heat produced by the retinal and choroidal surface, bringing the temperature toward room temperature (22°C, deep hypothermia). Temperature increases with endolaser treatment, air infusion, and the presence of silicone oil. The variations in temperature during vitreoretinal surgery are clinically significant, as the rheology of tamponades can be better manipulated by modulating intraocular pressure and temperature.ConclusionsDuring vitreoretinal surgery, the intraocular temperature showed rapid and significant fluctuations at different steps of the surgical procedure inside the vitreous cavity. Temperature control can modulate the rheology of tamponades.Translational RelevanceIntraoperative temperature control can improve neuroprotection during vitreoretinal surgery, induce the vaporization of perfluorcarbon liquid, and change the shear viscosity of silicone oil.
Highlights
During the last few years, intense research on the biological influence and control of temperature has transformed temperature into a new treatment approach for many human diseases.[1,2,3,4,5,6] Alterations of the body temperature of even only few degrees Celsius can have a strong direct or indirect influence on numerous biological processes
Based on the reported biological damage induced by variation of the temperature and on changes induced by temperature on the intraocular compounds, the aim of our study was to describe the best use of the temperature to perform a safer surgical procedures and the best pressure–temperature balance to manage the endotamponades
If we assume that the vapor phase is ideal, the partial pressure takes the form where CPC (Equation 2) is the molar density of perfluor-n-octane in vapor phase
Summary
During the last few years, intense research on the biological influence and control of temperature has transformed temperature into a new treatment approach for many human diseases.[1,2,3,4,5,6] Alterations of the body temperature of even only few degrees Celsius can have a strong direct or indirect influence on numerous biological processes. Mild to moderate hypothermia (T 1⁄4 328C–358C) can block the cascade of destructive inflammation, prevent blood–aqueous barrier disruption that leads to apoptosis[5] and local edema, and possibly stimulate the release of protective proteins. Other authors reported that reducing the temperature of plasma could kill pathogens, which was used to disinfect wounds, accelerate wound healing, and induce apoptosis of some cancer cells in vitro.[8] The application of mild to moderate hypothermia decreases neurological tissue damage caused by ischemia reperfusion, reduces the oxygen metabolic request, and induces the release of protective proteins.[5] maintaining body temperature between 328C to 348C is one of the treatment options for ischemic cardiac stroke, neurological injury, and neonatal encephalopathy. Mild to moderate hypothermia is TVST j 2016 j Vol 5 j No 1 j Article 4
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
