Abstract
Taxol is an antitumor compound which promotes assembly of microtubules in vitro . We report here that taxol promotes the initiation of microtubule assembly when injected into living eggs of Xenopus laevis . In unfertilized eggs injections of more than 0.50 ng of taxol induce microtubule formation into aster-like structures within 1 hr. This is accompanied by the formation of abnormal cleavage furrows. In fertilized eggs taxol arrests division in the injected blastomere of two- and four-cell embryos. Such arrested blastomeres contain asters and aster-like structures at higher taxol doses. The cleavage arrest caused by taxol injection was similar to the cytostatic activity of extracts from unfertilized eggs injected into embryos.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
