Abstract
Cisplatin is a non-specific platinum-based (derivative) chemotherapeutic agent that causes an increase in free radicals activity in the liver. Antioxidant activity of taxifolin has been demonstrated previously, and it has been reported that taxifolin inhibits the hydroxyl, radical in experimental studies. No studies were found in the current literature examining the protective effect of taxifolin on cisplatin-induced oxidative liver damage. We aimed to determine the protective effect of taxifolin on cisplatin-induced hepatotoxicity in an experimental study. In total, 18 albino Wistar male rats were assigned into 3 groups: healthy controls (HC group), 5 mg/kg of cisplatin administered for 8 days (CIS group) and 50 mg/kg of taxifolin + 5 mg/kg of cisplatin administered for 8 days (TCG group). Malondialdehyde (MDA), total glutathione (tGSH), total oxidant (TOS), and total antioxidant (TAS) capacity levels were measured in the extracted liver tissue. Liver tissue MDA and TOS levels were significantly higher in the CIS group. In contrast, tGSH and TAS levels were significantly lower in the CIS group, administered cisplatin alone (p < 0.001), compared to other groups. In the TCG group, administered cisplatin + taxifolin, MDA and TOS levels were significantly lower, whereas tGSH and TAS levels were significantly higher than in the CIS group (p < 0.001). These results suggest that taxifolin may be useful in preventing cisplatin-related liver injury.
Highlights
Cisplatin is a non-specific platinum-based chemotherapeutic agent that causes an increase in free radicals activity in the liver
These results suggest that taxifolin may be useful in preventing cisplatin-related liver injury
We investigated whether taxifolin (3,3′,4′,5,7-pentahydroxiflavanone), a flavonoid contained in onions, milk thistle, French maritime bark, and Douglas fir bark, has a protective effect against the hepatotoxicity of cisplatin.[13]
Summary
Cisplatin is a non-specific platinum-based (derivative) chemotherapeutic agent that causes an increase in free radicals activity in the liver. Cisplatin is a non-specific platinum-based (derivative) chemotherapeutic agent used to treat stomach, testis, ovarian, bladder, kidney, ureterovesical, head, and neck cancer.[1] It has been reported to cause serious toxic effects in many organs and systems during treatment.[2,3,4] The chemotherapeutic efficacy of cisplatin increases together with the dose. The oxidative stress induced by ROS causes a decrease in glutathione (GSH), which is an endogenous antioxidant
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