The effect of Tanreqing injection combined with conventional western medicine therapy on children with bronchioliti

Abstract

Objective To detect the effect of Tanreqing injection combined with conventional western medicine therapy on children with bronchioliti. Methods A total of 116 children with bronchioliti were enrolled in this study. Children were randomly divided into the control group (n=58) and Tanreqing injection observation group (n=58). The control group received continued low flow oxygen, anti-infection treatment, and salbutamol aerosol to relieve asthma. The observation group received Tanreqing injection based on the intervention of control group. Each group was treated for 7 d. The Th17 and Treg cells were detected by cytometry analysis and the expression of IL-17 and IL-10 were detected by ELISA analysis. The clinical effect of the two groups was compared. Results After treatment, compared with the control group, the Th17 cells (5.91%±0.83% vs. 7.23%±1.25%, t=2.346) and IL-17 (14.62±3.24 ng/ml vs. 22.52±5.14 ng/ml, t=2.412) decreased significantly, and the Treg cells (7.32%±1.24% vs. 5.32%±1.03%, t=2.352) and IL-10 (15.84±2.23 ng/ml vs.11.72±2.12 ng/ml, t=2.365) increased significantly in the observation group (P<0.05). The temperature recovery time (t=2.264, P=0.048), disappearance time of coughing (t=2.437, P=3.406), wheezing(t=2.258, P=2.352), pulmonary rales (t=0.032, P=0.034) and hospital duration (t=0.046, P=0.042) in the control group were significantly higher than those in the observation group. The clinical effective rate (94.8%, 55/58) in observation group was higher than that (79.3%, 46/58) in control group (χ2=2.327, P=0.041). Conclusion Tanreqing injection can regulate Th17/Treg cell balance, and its curative effect is superior to conventional therapy in children with bronchiolitis. Key words: Bronchioliti; Tanreqing injection; Th17 cells; Treg cells