The effect of systemic alfuzosin hydrochloride on choroidal thickness and pupil diameter sizes

Abstract

PurposeTo evaluate and investigate the effects of α1‐adrenoceptor antagonist alfuzosin hydrochloride on anterior and posterior segment findings using Sirius Scheimpflug/Placido photography‐based topography system and enhanced depth imaging spectral‐domain optical coherence tomography (EDI‐OCT).MethodsThis prospective study was performed with newly diagnosed benign prostatic hyperplasia, 25 eyes of 25 patients, initiated alfuzosin hydrochloride, were evaluated in this study. Anterior segment and posterior segment findings were noted at baseline, 1st and 3rd month. Results were compared statistically.ResultsThe mean subfoveal choroidal thickness 274.05 μm, and the mean 3 mm nasal thickness to the fovea 267.80 and the mean 3 mm temporal thickness to the fovea was 269.10 μm at baseline and they were 275.7 μm, 269.15 μm and 270.85 μm at 1st month and they were 278.10 μm, 271.40 μm and 273.25 μm at 3rd month, (p < 0.05, for all). The mean schirmer test values were 13.75–12.15 and 11.40 mm (respectively, at baseline, 1st and 3rd month) (p < 0.001). Besides, the mean scotopic and photopic pupil diameter values were 7.91 and 4.88 mm at baseline, and they were 7.47 mm and 4.38 mm at 1st month and 6.62–3.55 mm at 3rd month (p < 0.001).ConclusionsAlfuzosin caused a significant increase in choroidal thickness measurements. It was determined that significant decreases of scothopic and photopic pupil diameter sizes in pupillography, this reductions can be considered that alfuzosin may effect pupil size with blockade α‐adrenoceptors in iris dilator muscle of humans.