The Effect of Synthetic Polynucleotides on the Intracellular Growth of Brucella Abortus in vitro and in vivo

Abstract

SUMMARY The interferon-inducing synthetic polynucleotide pIpC restricted the growth of Brucella abortus 544 in calf kidney cell cultures. The non-interferon-inducing polynucleotide pApU exerted a marginal effect on brucella infection under these conditions. Both polynucleotides reduced the level of splenic infection with B. abortus 544 in Balb/C mice treated before inoculation. Neither polynucleotide was directly inhibitory for B. abortus 544 in vitro. It was concluded that interferon production probably played a minor role in controlling the intracellular growth of B. abortus in vivo.