Abstract
The effect of different doses of synthetic antioxidant b-(4-hydroxy- 3,5-ditertbutylphenyl), propionic acid (phenosan) and savory essential oil on the development of spontaneous leukemia was studied. The drug efficiency was determined from the survival curves, animal life spans, and the incidence of leukemia. Phenosan is characterized by clear antitumor activity in therapeutic (10 -4 mol/kg) and ultra-low (10 -14 mol/kg) doses. The dose of 10 -14 mol/kg increases the life span. The savory essential oil in low doses mixed with drinking water (150 ng/ml) or food (2,5 mg/g) increased the average lifetime of mice by 20-35 %. The low doses of these drugs seem promising as preventive drugs.
Highlights
One of the main consequences of exposure to harmful ecological factors is high risk of malignant diseases.The problem of malignant diseases prevention and the search for drugs decelerating or arresting the development of malignant neoplasms is very urgent
The drug efficiency was determined from the survival curves, animal life spans, and the incidence of leukemia
The savory essential oil in low doses mixed with drinking water (150 ng/ml) or food (2,5 mg/g) increased the average lifetime of mice by 20-35 %
Summary
One of the main consequences of exposure to harmful ecological factors (radiation, carcinogens, etc.) is high risk of malignant diseases.The problem of malignant diseases prevention and the search for drugs decelerating or arresting the development of malignant neoplasms is very urgent. We used b-(4-hydroxy3,5-ditertbutylphenyl) propionic acid (phenosan), an antioxidant of the hindered phenols class, as a possible prophylactic. This antioxidant was synthesized at the Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences (Moscow). It is known that many products of plant origin, i.e. herbs, spices, and their extracts, possess wide biological activity, including antioxidant and pharmacological properties [7, 12]. These compounds are applied in small doses; they have low toxicity and are recommended for use to decrease the risk of disease caused by increased oxidation of cell components
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
