Abstract
The triptans, serotonin receptor B/D agonists, are the mainstay in the acute treatment of migraine[1]. Sumatriptan, the first triptan, was originally developed as a cranial vasoconstrictor by acting on the 5-HT1B/1D receptors in cephalic vessels[2]. However, several modes of action as well as multiple sites of action have been proposed.[3]
Highlights
The triptans, serotonin receptor B/D agonists, are the mainstay in the acute treatment of migraine[1]
To explore a possible differential effect of sumatriptan on extra- versus intracerebral arteries, we examined the superficial temporal (STA), middle meningeal (MMA), extracranial internal carotid (ICAextra), intracranial internal carotid (ICAintra), middle cerebral (MCA) and basilar artery (BA)
The arterial circumference were recorded by high resolution magnetic resonance angiography before and after subcutaneous sumatriptan injection (6 mg) in 18 healthy volunteers
Summary
The triptans, serotonin receptor B/D agonists, are the mainstay in the acute treatment of migraine[1]. Objectives To explore a possible differential effect of sumatriptan on extra- versus intracerebral arteries, we examined the superficial temporal (STA), middle meningeal (MMA), extracranial internal carotid (ICAextra), intracranial internal carotid (ICAintra), middle cerebral (MCA) and basilar artery (BA).
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