The effect of sulfur atom on the biomedical properties of metal organic frameworks (MOF) prepared from mercaptosuccinic acid (MSA) and dimercaptosuccinic acid (DMSA) with Co(II), Ni(II), and Cu(II) ions

Abstract

Metal-organic frameworks (MOFs) were prepared at room temperature using natural occurring succinic acid derivatives, mercaptosuccinic acid (MSA), and dimercaptosuccinic acid (DMSA), as organic linker with Co(II), Ni(II), and Cu(II) as metal ions. The porosity, thermal, and structural properties of MSA- and DMSA-based Co(II), Ni(II) and Cu(II) MOFs were characterized and DMSA-Cu(II) MOFs were found to have higher surface area and lower pore size values, 73.7 m2/g, and 12.7 nm, respectively. The metal ion amount in MSA and DMSA-based MOF structures via Atomic Absorption Spectroscopy (AAS) analysis revealed an increased amount of Metal ions with the increasing number of −SH groups in the MOF structures. The antioxidant activities of DMSA-based MOFs were measured higher than MSA-based MOFs by ABTS•+scavenging assay. DMSA-Cu(II) MOFs showed higher antioxidant activity with 4.58 ± 0.13 μmol trolox g−1. Both MSA- and DMSA-MOFs presented hemocompatible behavior at concentrations < 100 µg/mL. Also, against B. subtilis and S. aureus bacteria strains, DMSA-Cu(II) MOFs showed higher antimicrobial activity than all the other prepared MSA- and DMSA-based MOFs with a MIC value of 31 µg/mL and MBC value of 125 µg/mL for both bacteria strains. Moreover, the MSA- and DMSA-MOFs at 250 μg/mL concentration retain about 80 % cell viability for L929 fibroblast cells at 24 incubation time.