Abstract
Objective To observe the protective role of sulfentanyl pretreatment on acute gastric mucosal lesion induced by water immersion restraint stress (WIRS) in diabetic rats and investigate its' possible mechanism.Methods The acute gastric mucosal lesion models were copied by the classic WIRS,Fifty adult SD rats were randomly divided into five groups (n=10),including normal rats (group A),normal rats suffering WIRS (group B1),diabetic rats suffering WIRSs (group B2),normal rats suffering WIRS pretreated with sufentanil (group C1),diabetic rats suffering WIRS pretreated with sufentanil (group C2),all the experimental rates were killed at 6 h after WIRS for stomach samples.Gastric mucosal injury index (GI) was assessed thought 10x dissecting microscope and pathologic histology were observed under optical microscope of each group.Myeloperoxidase (MPO) of gastric tissue homogenate were measured with chromatometry.Results ① Acute gastric mucosal lesions were found in All rats suffered WIRS.And GI of each group was as follow (B1:27.3±4.6,B2:34.6±6.1,C1:3.9±0.9,C2:3.9±0.7),GI is significantly higher in group B2 vs.group B1 and C1 (P＜0.05).② There were significantly higher valuer of MPO in group B1 and group B2 vs.group A.③ It can be found diversity degree of engorgement hydropsia and inflammatory cell infiltrate in those rats' gastric mucosa 6 h after WIRS,those symptom is wost in group B2 and better in groups which were pretreated with sufentanil.④ Correlation analysis showed there was a positive correlation between the GI and tissue MPO(r=0.967,P＜0.01).Conclusions The diabetic rats will suffer severer injure of stomach mucous membrane than normal rats.Pretreatment with sufentanil can effectively protect stomach mucous membrane from WIRS-induced injury,and the possible mechanism are the lipid peroxidation depression,oxygen radicals release and neutrophils increase. Key words: Sufentanil; Diabetes mellitus; Disease, acute gastric mucosal lesion; Myeloperoxidase
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Anesthesiology and Resuscitation
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
