Abstract
The effect of suckling on the course of experimental staphylococcal mastitis in the mouse was to induce a spectrum of histopathological changes. These changes extended from complete liquefactive necrosis of the gland to the involvement of isolated areas of the gland in a chronic response. The reactions in suckling mice were compared with the acute reaction to intramammary inoculation of staphylococci in non-suckling mice and with the chronic reaction to intramammary inoculation of staphylococci in mice pre-inoculated with endotoxin by the intramammary route. By inoculating suckling mice with organisms suspended in an irritant (endotoxin) or an anti-inflammatory agent (dexamethosone) the response was predominately chronic or acute respectively. The value of the study was to reveal the various pathways along which pathological changes in the mammary gland may proceed.
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