The effect of Succinate injection combined with Bifico on the myocardial enzymes changes of the children with rotavirus enteritis

Abstract

Objective To observe the effect of Succinate injection combined with Bifico on the myocardial enzymes changes of the children with rotavirus enteritis. Methods A total of 146 children with rotavirus enteritis were enrolled and included in this study. Children were randomly divided into the control group (n=73) and the observation group (n=73). The control group was received Bifico on the basis of routine treatment, and observation group was received Succinate injection combined with Bifico. The IL-17, IL-6, TNF-α, LDH, CK, and CKMB was detected by ELISA. The rates of clinical effects was compared. Results After treatment, the IL-17 (22.35 ± 4.21 ng/ml vs. 30.24 ± 6.07 ng/ml, t=2.395), IL-6(31.26 ± 6.14 ng/ml vs. 43.72 ± 8.22 ng/ml, t=2.347), TNF-α (35.62 ± 6.24 ng/ml vs. 49.18 ± 8.72 ng/ml, t=2.421), LDH (135.16 ± 31.25 U/L vs. 174.08 ± 40.22 U/L, t=2.373), CK (37.82 ± 7.39 U/L vs. 50.21 ± 11.16 U/L, t=2.385), and CKMB (90.14 ± 11.63 U/L vs. 113.22 ± 18.35 U/L, t=2.392) in the observation group were lower than those in the control group (P<0.05). The rates of clinical effects was 94.5% (69/73) in the observation group and 83.6% (61/73) in the control group. There was significant difference between the two groups (χ2=2.352, P=0.047). Conclusions The Succinate injection combined with Bifico could reduce the inflammatory indices and alleviate the myocardial injury in the RVE patients. Key words: Enteritis; Rotavirus infections; Succinate injection; Bifico; Myocardial enzymes