Abstract
THE EFFECT OF SUBSTANCES RELATED TO THE TRICARBOXYLIC ACID CYCLE UPON KETOSIS
Highlights
The administration of various precursors of oxalacetic acid and oxalacetic acid itself caused a decrease in total urinary ketone body excretion in rats made ketotic with butyric acid
Inositol caused a decrease in ketonuria in animals fed butyrate. 3
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Summary
Through a subsequent series of oxidations and decarboxylations, water and carbon dioxide equivalent to the acetic acid are formed and oxalacetic acid is regenerated, thereby completing the oxidative cycle. This indicates the necessity of a sufficient quantity of oxalacetic acid to enable the partially metabolized products of the fatty acids to enter the tricarboxylic acid cycle and be completely oxidized. The work reported here was undertaken in order to study the effects in vivo of various oxalacetic acid precursors, especially those present in the tricarboxylic acid cycle, as well as oxalacetic acid itself, on ketonuria in rats fed butyric acid. That the in vivo administration of a member of the tricarboxylic acid cycle such as malic acid may cause an increase in the other members of the cycle, such as cu-ketoglutaric acid, has been demonstrated by Krebs et al [7]
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