Abstract
The aim of this study was comparing the analgesic effects of subpleural ketamine and bupivacaine on post thoracotomy pain. This clinical trial included the patients older than 18 years old who had been selected for elective thoracotomy. After the operation, we administered ketamine or bupivacaine on the patients after they became conscious. The next doses of drugs were infused in 8, 16, and 24 hours later. The pain was assessed by the Visual Analog Scale (VAS). The data was analyzed using the SPSS software. Before the administration of the drugs, the VAS point in the ketamine group was significantly higher than in the bupivacaine group. But there was no significant difference one hour after the administration of the drugs between the VAS point in the ketamine and bupivacaine groups. Our results show that analgesic effects of subpleural administration of ketamine and bupivacaine on the post-thoracotomy pain after one hour had no significant difference. But after 8 hours, the analgesic effect of ketamine is significantly lower than bupivacaine. This may due to the shorter half life of the ketamine. We suggest that at clinical administration, the interval between subpleural ketamine be shorter than 8 hours.
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