Abstract
Spherical materials with hollow cores have received tremendous attention since they possess extraordinary drug-loading capacity and sustained controllably release property. In this work, hollow bioactive glass nanospheres (HBGNs) through a novel and facile method employing polyacrylic acid (PAA) as the sacrificial template firstly were regulated by doping strontium/copper (Sr/Cu). The corresponding morphology, structure, physicochemical properties, and apatite-mineralization ability of Sr/Cu-doping HBGNs (Sr/Cu-HBGNs) have been thoroughly investigated. It was seen notably the loading efficiency of HBGNs, 5Sr-HBGNs rose from 4.97 ± 2.29%, 10.02 ± 2.93% to 84.94 ± 0.77%, 87.91 ± 0.23% after vancomycin hydrochloride (VAN) content increased, while that of 5Cu-HBGNs had negative impact from 2.14% ± 1.41% to 5.58 ± 2.55%. Meanwhile, they were pH and temperature sensitive. Thereby, Sr-HBGNs with excellent surface nature, biodegradability and biocompatibility can potentially be utilized as injectable and drug-loading biomaterials for in vitro tissue regeneration and drug control release.
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