Abstract
A study was made of the effect produced by the stereoisomers of cycloserine on decarboxylization of glutamic acid and transamination of γ-aminobutyric acid with α-ketoglutaric acid in the homogenates of the rat brain at pH 7.5. As revealed. D.L-cycloserine in a concentration of 10−3 M depressed the first process by 40% and the second one by 45%. In the same conditions D-cycloserine depressed glutamic acid decarboxylation by 9%; it somewhat activated γ-aminobutyric acid transamination. A discussion is presented on the possible effect of cycloserine isomers on the content of free γ-aminobutyric acid in the brain (in vivo) following the administration of isoniazid in large doses.
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