Abstract

Background. Little is known about the effect of statins addition to standard antihypertensive therapy on blood pressure level and vascular stiffness in high-risk hypertensive patients.The aim of the study was to assess the dynamics of vascular stiffness in hypertensive patients of high or very high cardiovascular risk under the influence of rosuvastatin addition to combined two-component amlodipine and lisinopril antihypertensive therapy.Materials and methods. We investigated 60 hypertensive patients who were randomized into two groups: the 1st group received a fixed amlodipine/lisinopril combination, the 2nd one followed the same regimen of therapy with addition of 20 mg rosuvastatin. Mean office and ambulatory blood pressure as well as central aortic blood pressure and pulse wave velocity were evaluated in both groups before and after 24-week follow-up period.Results. At end of follow-up period the office and average daily blood pressure significantly decreased in both groups, with more prominent office diastolic blood pressure decline in the 2nd one. The central aortic blood pressure equally decreased in both groups. The augmentation index significantly reduced in both groups, mostly in the 2nd one. The carotid-femoral pulse wave velocity declined in both groups to the same extent. The carotid-radial pulse wave velocity decreased statistically only in the second group.Conclusions. Addition of rosuvastatin to a fixed amlodipine/lisinopril combination in high/very high cardiovascular risk hypertensive patients was accompanied by more pronounced decline of diastolic blood pressure and augmentation index, as well as significantly reduction of pulse wave velocity.

Highlights

  • Little is known about the effect of statins addition to standard antihypertensive therapy on blood pressure level and vascular stiffness in high-risk hypertensive patients

  • We investigated 60 hypertensive patients who were randomized into two groups: the 1st group received a fixed amlodipine/lisinopril combination, the 2nd one followed the same regimen of therapy with addition of 20 mg rosuvastatin

  • At end of follow-up period the office and average daily blood pressure significantly decreased in both groups, with more prominent office diastolic blood pressure decline in the 2nd one

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Summary

ВНУТРЕННИЕ БОЛЕЗНИ INTERNAL DISEASES

Цель исследования: изучить динамику показателей сосудистой жёсткости у больных артериальной гипертензией высокого или очень высокого сердечно-сосудистого риска при добавлении розувастатина к комбинированной двухкомпонентной антигипертензивной терапии амлодипином и лизиноприлом. Каротидно-феморальная скорость распространения пульсовой волны снизилась в одинаковой степени в обеих группах, а каротидно-радиальная – только во второй (с 9,5 ± 1,8 до 8,8 ± 1,1 м/с; р = 0,026). Добавление розувастатина к фиксированной комбинации амлодипин/лизиноприл в лечении больных артериальной гипертензией высокого и очень высокого сердечно-сосудистого риска сопровождалось более выраженным снижением офисного диастолического давления, индекса аугментации и статистически значимо уменьшало каротидно-феморальную и каротидно-радиальную скорость распространения пульсовой волны. Ключевые слова: артериальная гипертензия, розувастатин, лизиноприл, амлодипин, жёсткость сосудов, скорость распространения пульсовой волны. Влияние статина при добавлении к антигипертензивной терапии на показатели сосудистой жёсткости у больных артериальной гипертензией высокого сердечно-сосудистого риска. Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuing Professional Education (664049, Irkutsk, Yubileyniy, 100, Russian Federation)

Background
Results
МАТЕРИАЛ И МЕТОДЫ
Internal diseases
ЛИТЕРАТУРА REFERENCES

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