Abstract
Posterior fusions performed in immature beagles resulted in significant compositional changes of the discs encompassed by the fusion and those adjacent to it. By 6 months postoperation, a fall in collagen and a rise in noncollagenous protein content in the nucleus pulposus had taken place. Total nitrogen values were essentially unchanged. Although hexosamine levels were only minimally reduced as compared to control nuclear tissue, a significant alteration in the glucosamine and galactosamine distribution took place (after 6 months), both in the nucleus pulposus and the annulus fibrosus. In conjunction with uronic acid analysis, these changes are interpreted as a possible rise in the level of hyaluronic acid in the surgical and parasurgical discs. The significance of these findings is discussed in relation to the role of spinal fusion in the treatment of spinal disease and disorder.
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