Abstract
Spinal cord transection at the level of C-7 dramatically protected rats against the hepatotoxic effects of an orally administered dose of carbon tetrachloride. However, complete protection was not achieved. The degree of protection diminished as the level of cord transection was lowered from C-7 to L-4. Cord sectioning seemed to aggravate the degenerative response elicited after exposure to low doses of carbon tetrachloride. C-7 transection generally afforded protection regardless of the route of administration employed. A time study revealed that after oral administration the development of the hepatic lesion in C-7 sectioned rats paralleled that in intact rats for the first few hours. These findings are compatible with the idea that the primary event in carbon tetrachloride hepatotoxicity is a direct action of the agent on the parenchyma.
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