The effect of sperm parameters on the outcome of ICSI-ET cycle in poor responder women ≤35 years old

Abstract

To investigate whether sperm parameters affect fertilization, cleavage and clinical pregnancy rates in poor responder women aged ≤ 35 years and undergoing ICSI-ET cycle. Retrospective analysis of ICSI-ET cycles performed in the same center. A total of 432 women who produced less than 5 oocytes as a response to ovulation induction were analyzed. All women with normal uterine cavity diagnosed with HSG and underwent first ICSI-ET cycles were included. Sperm parameters were divided into 4 groups: Severe OAT (sperm concentration: ≤ 1 million [/ ml, motility:< 25 % and morphology: 0%), OAT (sperm concentration: 1to 15million [/ ml, motility: < 25 % and morphology: 1to4%), normal (sperm concentration:>15 million [/ ml motility: > 25%, morphology:≥ 4%), testicular sperm obtained with TESE (Testicular sperm extraction). Statistical analysis … Fertilization, cleavage and clinical pregnancy rates (CPR) were compared among the groups. Fertilization, cleavage and CPR were similar in OAT, severe OAT and normal sperm parameters group (p>0.05). Fertilization rate in TESE group was significantly lower than other 3 groups (p<0.01). Cleavage and CPR did not differ among all groups (p>0.05).Tabled 1Cycle characteristics and outcomes according to the sperm parametersNormal (n?267)OAT (n)?104Severe OAT (n?35)TESE (n?26)P valueAge31.8 ±2.132.3 ±1.831.7 ±1.430.9 ±2.2NSNo of oocytes collected2.8 ± 1.13.1 ±1.12.9 ± 1.23.2 ± 1.2NSFertilization rate (%)76.276.474.257.4*Embryo Transfer, NS ; not significant.0.007Cleavage Rate (%)78.582.881.887.2NSEmbryos per ET*Embryo Transfer, NS ; not significant.1.6 ± 0.31.3 ± 0.41.4 ± 0.51.3 ± 0.4NSImplantation rate (%)(94)? 464 (20.2)38? 168 (22.6)11? 58 (18.9)10? 43 (23.2)NSClinical pregnancy rate (%)80 (29.9)33 (31.7)10 (28.6)9 (34.6)NS* Embryo Transfer, NS ; not significant. Open table in a new tab Fertilization rate is decreased with testicular sperm found in men with different etiologies. Otherwise, sperm parameters do not affect cleavage and clinical pregnancy rates in poor responder women aged ≤35 years.