Abstract
The following compounds (known to bind to DNA) were tested for their effect on split-dose sparing in yeast cells: acriflavine (10/sup -4/ m), hydroxylamine (10/sup -2/ m), caffeine (0.5%), formaldehyde (10/sup -3/ m), and actinomycin D (5 g/ml). Stationary diploid yeast cells were exposed to ultraviolet (254 nm) or 12-MeV electrons, using doses to result in a colony- forming ability of about 50% after one fraction (2 x 50 krad or 2 x 1180 erg mm/ sup -2/, respectively). The sparing effect of dose fractionation was inhibited with all compounds, except for acriflavine (ineffective with uv irradiation) and formaldehyde which prevented sparing only under hypoxic conditions. (UK)
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