Abstract
Abstract The effects of atropine and some quaternary derivatives on the inhibitory responses of the Finkleman preparation to stimulation of the periarterial sympathetic nerves and to added adrenaline were examined. None of the compounds tested appeared to affect the inhibitory responses with the exception of N-diphenylmethylatropine, which much enhanced the inhibitory effect of the electrical stimulation. In addition, this compound antagonised in vitro, but not in vivo, the activity of several adrenergic neurone blocking compounds, but not guanethidine.
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