The Effect of Solvents to Extract Phenol and Phenol Related Compounds Contents and SomeBiological Screening of Salvia officinalis

Abstract

Saliva officinalis (Lamiaceae) herbal plant collected from Khartoum local market. This study hasthree aims, to assess the efficacy of three aqueous organic solvents to extract the phenol and phenolderivative metabolites using the maceration method, to assess the antifungal and anticancer ofSaliva officinalis aqueous extracts using Yeast – Based bioassay against three mutant yeast strainsSaccharomyces cerevisiae, and to assess the antioxidant activity of Saliva officinalis extracts usingtwo methods: DPPH radical scavenging assay, and TLC Autography technique. The resultsrevealed that the 70% methanol has high total phenols (318.35mg GAE/g) and total flavonoids(189.38mg QE/g) while the 70% acetone extract was revealed high total tannin content (218.34 mgTAE/g). The 70% acetone extract revealed activity against the three mutant yeast tested withinhibition zone diameter more than 12 mm at concentration 5mg/ml and 10mg/ml respectively.While the other extracts were exhibited no activity against the three mutant strains tested. Allextracts were reflected anti-Candida activity and the maximum IZD was exhibited by the70%ethanol extract (30mm). All extracts were free-radical inhibitors but 70% methanol extract wasmore potent (0.068mg/ml) than the other extracts